Pavel Krejci Selected Research

Achondroplasia

1/2022	A registry of achondroplasia: a 6-year experience from the Czechia and Slovak Republic.
1/2021	An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice.
1/2019	C-Type Natriuretic Peptide Analogue Therapy in Children with Achondroplasia.
1/2018	Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies.
1/2016	Multikinase activity of fibroblast growth factor receptor (FGFR) inhibitors SU5402, PD173074, AZD1480, AZD4547 and BGJ398 compromises the use of small chemicals targeting FGFR catalytic activity for therapy of short-stature syndromes.
4/2015	Neutral endopeptidase-resistant C-type natriuretic peptide variant represents a new therapeutic approach for treatment of fibroblast growth factor receptor 3-related dwarfism.
1/2012	Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias.
11/2005	Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis.

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Pavel Krejci Research Topics

Disease

12	Neoplasms (Cancer) 01/2022 - 08/2007
8	Achondroplasia 01/2022 - 11/2005
5	Dwarfism 01/2021 - 07/2010
5	Chondrosarcoma 01/2017 - 11/2005
4	Multiple Myeloma 10/2016 - 06/2009
2	Breast Neoplasms (Breast Cancer) 01/2020 - 01/2018
2	Carcinoma (Carcinomatosis) 04/2012 - 07/2010
1	Spondylocarpotarsal synostosis 04/2022
1	Intervertebral Disc Degeneration 04/2022
1	Osteogenesis Imperfecta (Lobstein Disease) 01/2022
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 01/2022
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2022
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2022
1	Developmental Bone Diseases (Bone Dysplasia) 12/2020
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 10/2020
1	Oculocerebrorenal Syndrome (Lowe Syndrome) 01/2020
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2020
1	Glioblastoma (Glioblastoma Multiforme) 01/2020
1	Opsismodysplasia 01/2020
1	Muscular Dystrophies (Muscular Dystrophy) 01/2020
1	Yersinia Infections 01/2018
1	Thanatophoric Dysplasia (Dwarfism, Thanatophoric) 01/2018
1	Ciliopathies 01/2018
1	Craniosynostoses (Craniosynostosis) 12/2017
1	Hepatocellular Carcinoma (Hepatoma) 01/2017
1	Lung Neoplasms (Lung Cancer) 10/2016
1	Rhabdomyosarcoma 10/2016
1	Aneuploidy (Aneuploid) 05/2016
1	Short Rib-Polydactyly Syndrome 01/2016
1	Urinary Bladder Neoplasms (Bladder Cancer) 01/2014
1	Muscle Hypotonia (Hypotonia) 07/2013
1	Polycythemia (Erythrocytosis) 07/2013
1	Failure to Thrive 07/2013
1	Intellectual Disability (Idiocy) 07/2013
1	Leukopenia 07/2013
1	Seizures (Absence Seizure) 07/2013
1	Neutropenia 07/2013
1	Skin Abnormalities 06/2012
1	Acrodysostosis 04/2012
1	Colorectal Neoplasms (Colorectal Cancer) 04/2012
1	Lymphoid Leukemia 12/2007

Drug/Important Bio-Agent (IBA)

5	Phosphotransferases (Kinase)IBA 01/2022 - 06/2012
5	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2022 - 07/2010
5	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2017 - 03/2007
5	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 01/2016 - 06/2009
4	Proteins (Proteins, Gene)FDA Link 12/2020 - 12/2007
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2021 - 01/2017
2	Tyrosine Kinase InhibitorsIBA 10/2020 - 12/2017
2	C-Type Natriuretic Peptide (Peptide, C-Type Natriuretic)IBA 01/2019 - 04/2015
2	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 01/2018 - 04/2015
2	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 10/2016 - 04/2015
1	mouse FLNB proteinIBA 04/2022
1	Nonsense Codon (Nonsense Mutation)IBA 04/2022
1	FilaminsIBA 04/2022
1	Procollagen Type IIBA 01/2022
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2022
1	Cell Surface ReceptorsIBA 01/2022
1	4-phenylbutylamineIBA 01/2022
1	alpha2 Subunit Collagen Type IIBA 01/2022
1	LigandsIBA 01/2021
1	Laminin (Merosin)IBA 12/2020
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2020
1	ColicinsIBA 01/2018
1	phosphoinositide-3,4-bisphosphateIBA 01/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2018
1	AZD 1480IBA 12/2017
1	derazantinibIBA 12/2017
1	Tec protein-tyrosine kinaseIBA 01/2017
1	Protein Kinases (Protein Kinase)IBA 01/2017
1	dichlorobis(azomycin)platinum IIIBA 05/2016
1	vosoritideIBA 04/2015
1	Neprilysin (Neutral Endopeptidase)IBA 04/2015
1	Biological ProductsIBA 01/2014
1	Transcription Factors (Transcription Factor)IBA 01/2014
1	Tyrosine (L-Tyrosine)FDA Link 01/2014
1	Fumaric aciduriaIBA 07/2013
1	Fumarate Hydratase (Fumarase)IBA 07/2013
1	EnzymesIBA 07/2013
1	Hormones (Hormone)IBA 04/2012
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 04/2012
1	Epithelial Cell Adhesion MoleculeIBA 04/2012
1	Nuclear Proteins (Protein, Nuclear)IBA 04/2012
1	4,4,',4'',4'''- (carbonylbis(imino- 5,1,3- benzenetriylbis(carbonylimino)))tetrakis(benzene- 1,3- disulfonate)IBA 07/2010
1	ChemokinesIBA 07/2010
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 06/2009
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 08/2007
1	Fibroblast Growth Factor 1 (FGF-1)IBA 03/2007
1	Protein Kinase CIBA 02/2007
1	bisindolylmaleimide IIBA 02/2007
1	Mitogen-Activated Protein KinasesIBA 11/2005
1	Natriuretic PeptidesIBA 11/2005

Therapy/Procedure

4	Therapeutics 01/2019 - 07/2010
1	Subcutaneous Injections 01/2021